Epigenetics, Heredity, and Aging

Thermodynamics of Aging and Heredity

A brief review of the author’s works in the sphere of thermodynamic theory of aging is presented. Particular attention is given to justification of the methods of classical and near-equilibrium “dynamic” thermodynamics used to assess the direction and extent of ontogenesis. It is noted that discovery of the law of temporal hierarchies and the substance stability principle made it possible to us...

Epigenetics and aging

Aging is the accumulation of changes in an organism over time that leads to reduced viability. Studies in model organisms indicate that aging is genetically determined and that alterations to specific genes can extend or shorten lifespan. Some organisms exhibit negligible aging with no loss of metabolic functions or fertility over time, despite a high metabolic rate, raising the question as to ...

Epigenetics and aging.

Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks, such as DNA methylation and numerous histo...

Epigenetics and aging

Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones...

Patterns of Heredity and Genetic Alteration; Epigenetics of Mammals